Nelson, PP 2025, 'Mining as a living system: insights from human biology for sustainable operations', in AB Fourie, A Copeland, V Daigle & C MacRobert (eds), Paste 2025: Proceedings of the 27th International Conference on Paste, Thickened and Filtered Tailings, Australian Centre for Geomechanics, Perth, pp. 3-20, https://doi.org/10.36487/ACG_repo/2555_0.01 (https://papers.acg.uwa.edu.au/p/2555_0.01_Nelson/) Abstract: Mining operations can be understood as living systems, with processes and impacts analogous to human body systems. Material flow mirrors the circulatory system, while ecosystems act as vital organs – lungs, kidneys, and skin – providing essential functions such as water purification and air quality regulation. Communities, akin to the nervous and immune systems, deliver critical feedback and resilience, enabling mining operations to adapt and thrive amidst challenges. This paper explores these biological analogies to explore a systems-thinking framework for mining operations, emphasising the balance between operational efficiency, environmental stewardship and social priorities. Key strategies include adaptive management, biologically inspired innovations and integration of circular economy principles. By rethinking tailings as resources, leveraging real-time monitoring for proactive risk management and constructing climate-resilient infrastructure, the mining industry can address cascading effects and systemic interdependencies. This integrated approach enhances operational resilience, minimises risks and aligns mining practices with sustainability goals, laying the groundwork for the long-term success of both the industry and surrounding communities. Keywords: mining systems, responsible mining, sustainability, biologic systems, adaptive management, circular economy, tailings management